Ik zal een stukje van hun theorie plaatsen,qua overdracht.(wel engels

) In our breed the preliminary data suggest that DCM is typically inherited in an X-linked recessive fashion. This means that usually unaffected, but carrier, dams pass on the defective X chromosome to statistically 50% of their offspring. When this is a bitch pup, she will also be an unaffected carrier like her dam. When this is a dog pup, he will suffer from DCM as an adult dog. This is because male dogs only have one X chromosome; the other sex chromosome being the Y chromosome inherited from their sire (which made them male). Affected males will produce 100% carrier daughters, as they give this defective X chromosome to all their female offspring. Then these carrier daughters produce again affected sons. However, when a disease is X-linked, the sons of an affected sire are NOT at risk, as they do not inherit an X chromosome from their sires. Females can also be affected (i.e. develop DCM), although this is more rare. With an X-linked recessive disease females have TWO defective X-chromosomes. If used in a breeding program, such a bitch would produce 100% affected sons and 100% carrier daughters bred to a clear dog. If an affected dog was used on a carrier bitch, then 50% of the male pups would be affected, 25% of the female pups would also have DCM, with the other 25% would be DCM carriers. So to summarize, X-linked recessive disorders are: seen with much more frequency in males than in females, are a trait never transferred directly from father to son, and have the appearance of skipping a generation because it's transmitted through carrier females typically. DCM is obviously a serious enough disease that it's wise for breeders to learn about the method of inheritance and they should track its progression through various generations, thereby attempting to predict carrier status and thus reducing the number of potentially affected dogs.